Accidental opioid poisoning can happen to any of your patients taking opioids1
The opioid crisis has unearthed the devastating effects opioids are having on individuals, families and communities across Canada.2 Much of the focus has been on the contribution of illicit drugs.2 However, prescription drugs have also contributed to the crisis since an accidental opioid poisoning can happen to any of your patients taking opioids.1 So, we partnered with pharmacists like you to talk about how we can help make a difference.1
Indications and clinical use: NARCAN® NASAL SPRAY is a pure opioid antagonist indicated for emergency use to reverse known or suspected opioid overdose, as manifested by respiratory and/or severe central nervous system depression.
- NARCAN® NASAL SPRAY can be administered by a bystander (non-health care professional) before emergency medical assistance becomes available, but it is not intended to be a substitute for professional medical care. Emergency medical assistance (calling 911) should be requested immediately when an opioid overdose is suspected, before administering naloxone.
About This Series
In Ontario alone, 53% of patients hospitalized due to opioid-related reasons had an active opioid prescription.9 This means pharmacists are in a unique position to help make a difference in the opioid crisis.1 We created this series with pharmacists like you to discuss the role of prescriptions in the opioid crisis, bias and stigma, techniques on how to start conversations with your patients about NARCAN® Nasal Spray, and simple everyday habits you can apply to your practice.
Meet the pharmacists who helped develop the articles and videos
Vinita Arora
BScPhm, ACPR, MEd, PharmD
Michael Beazely
BSP, PhD
Michael Boivin
RPh, CDE
Shelita Dattani
BScPhm, PharmD
Philippe
De GrandpréBScPhm
Julie Laroche
BScPhm
Aaron Sihota
BSc, BScPharm, RPh
Ross T. Tsuyuki
BScPharm, PharmD, MSc, FCSHP, FACC, FCAHS, ISHF
The above pharmacists are members of the NARCAN® Advisory Board. They are under contractual agreement with Emergent BioSolutions Canada Inc., and some have received compensation for their time and contribution.
Always offer a take-home naloxone kit–available as either a nasal spray, like NARCAN® Nasal Spray, or an injection–to any patient receiving an opioid prescription.1,3
Safety information10
Indications and clinical use:
NARCAN® NASAL SPRAY is a pure opioid antagonist indicated for emergency use to reverse known or suspected opioid overdose, as manifested by respiratory and/or severe central nervous system depression.
NARCAN® NASAL SPRAY can be administered by a bystander (non-health care professional) before emergency medical assistance becomes available, but it is not intended to be a substitute for professional medical care. Emergency medical assistance (calling 911) should be requested immediately when an opioid overdose is suspected, before administering naloxone.
Contraindications:
Patients who are hypersensitive to this drug or to any ingredient in the formulation or component of the container.
Serious warnings and precautions:
- Call 911: Emergency medical assistance (calling 911) should be requested immediately when an opioid overdose is suspected, before using naloxone.
- Continued surveillance: Individuals with a satisfactory response to an initial dose of naloxone should be kept under continued surveillance.
- Aggressive reactions: Caregivers administering naloxone should be prepared to act in response to or assist the patient in cases of potential adverse reactions such as aggressive reactions, convulsions and vomiting. Special attention is warranted if naloxone is administered to a neonate or a pregnant woman.
Other relevant warnings and precautions:
- In opioid dependent people, naloxone may trigger an acute opioid withdrawal syndrome; this may be life-threatening in opioid dependent neonates
- Preterm labour or fetal distress in opioid dependent pregnant women
- Rebound opioid toxicity, including respiratory depression, following the temporary reversal of the opioid overdose
- Ineffective against respiratory depression due to non-opioid drugs
- Cardiovascular risks including rare cases of cardiac arrest, tachycardia and ventricular fibrillation
- Post-operative considerations including hypotension, hypertension, ventricular tachycardia and fibrillation, dyspnea, pulmonary edema and rare cases of cardiac arrest. Death, coma, and encephalopathy have been reported as sequelae of these events
- Convulsions or seizures
- Irritability and aggressive behaviour
- Gastrointestinal reactions including diarrhea, nausea, vomiting and abdominal cramps
- Use in nursing women has not been established
- Higher systemic exposure in geriatrics
For more information:
Please consult the product monograph at narcannasalspray.ca/pdf/NARCAN%C2%AE-Nasal-Spray-product-monograph-Mar%2005-2021-red-plunger.pdf for important information relating to contraindications, adverse reactions, drug interactions, patient selection and dosing information.
The product monograph is also available by calling 1-844-898-0657.
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Frequently Asked Questions
Can NARCAN® Nasal Spray be used on pregnant women?
- NARCAN® Nasal Spray should only be used in pregnant women when clearly needed.10
Giving NARCAN® Nasal Spray to anyone who is physically dependent on opioids may induce an acute opioid withdrawal syndrome causing a reaction such as becoming aggressive, shaking and/or vomiting. You will need to pay special attention when giving NARCAN® Nasal Spray to a pregnant woman because some of these reactions may cause preterm labour or can be life threatening to the fetus. Emergency medical assistance (calling 911) should be requested immediately when an opioid overdose is suspected, before administering NARCAN® Nasal Spray.10
Please see the product monograph and patient information for a full list of warnings and precautions:
For health care professionals:
For patients: Can NARCAN® Nasal Spray be used on a child?
- Yes, it can, but there are a few considerations:
Newborns:
You may need to help the person who received NARCAN® Nasal Spray. The patient may have a reaction such as becoming aggressive, shaking and/or vomiting. You will need to pay special attention when giving NARCAN® Nasal Spray to a newborn who is less than four weeks old or a pregnant woman. Some of these reactions can be life-threatening for a newborn or a fetus. Emergency medical assistance (calling 911) should be requested immediately when an opioid overdose is suspected, before administering NARCAN® Nasal Spray.10
The pharmacist may recommend using an alternate form of naloxone in newborns or children under two years old. This is because smaller doses can be given with the injectable form of naloxone.10
Children:
When administering NARCAN® Nasal Spray in young children, the nozzle of the device may not fit inside the child’s nostril. In this case, make sure that the device nozzle forms a seal with the nostril before giving NARCAN® Nasal Spray.10
Please see the product monograph and patient information for a full list of warnings and precautions:
For health care professionals:
For patients: Can NARCAN® Nasal Spray be used past its expiration date?
- NARCAN® Nasal Spray should be used before the expiration date on the box. However, if only expired NARCAN® Nasal Spray is available in an overdose situation, it should be used.10
What are the withdrawal symptoms that occur when you use NARCAN® Nasal Spray? What should you be prepared for?
- NARCAN® Nasal Spray should be administered with caution to patients who are known or suspected to be physically dependent on opioids. In such cases, an abrupt reversal of opioid effects may precipitate an acute opioid withdrawal syndrome. The severity of such a syndrome will depend on the degree of physical dependence, the dose and potency of the opioid that induced the overdose, and the dose of naloxone administered.10
The signs and symptoms of an acute opioid withdrawal syndrome include, but are not limited to: body aches, pain, fever/pyrexia, sweating/hyperhidrosis, runny nose, sneezing, piloerection, yawning, weakness, asthenia, shivering, chills, tremor/trembling, convulsions/seizures, nervousness, restlessness, irritability, aggressive behavior, diarrhea, nausea, vomiting, abdominal cramps, increased blood pressure, and tachycardia. In the dependent neonate, signs also include excessive crying as well as hyperactive reflexes and the acute withdrawal may be life-threatening if not recognized and properly treated.10
Emergency medical assistance (i.e., calling 911) should be requested immediately when an opioid overdose is suspected. Monitor the patient for the development of the signs and symptoms of opioid withdrawal. Caregivers administering naloxone to any patient should always be prepared for potential reactions associated with acute opioid withdrawal syndrome and to assist the patient to minimize harm when experiencing these reactions. For example, a patient should be positioned in lateral decubitus to prevent choking if vomiting occurs; sharp or dangerous objects should be moved away in case of convulsions to protect the patient from injury, but the patient should not be restrained.10 How does reimbursement work? Can you give it to someone without ID?
- NARCAN® Nasal Spray is available at pharmacies in Ontario as part of the Ontario Naloxone Program for Pharmacies (ONPP), and in Quebec as part of the Program for Free Access to Naloxone and Certain Related Supplies implemented by the Ministère de la Santé et des Services sociaux.11,12
NARCAN® Nasal Spray is also available for Veteran Affairs Canada clients, Non-Insured Health Benefits (NIHB) program clients, and First Nations Health Authority (FNHA) clients in British Columbia.13-15
Patients can request NARCAN® Nasal Spray without providing a prescription or an ID, helping them protect their privacy.16- In Ontario, for anonymous patients or those without an Ontario health card, use the following information:11
First and last name: HARM REDUCTION
Gender: blank
DOB: 20000101
Proxy patient ID: 89999 999 91 - In Quebec, a health card may not be required to receive it; it can be supplied anonymously, especially in case of emergency.12,17
- In Ontario, for anonymous patients or those without an Ontario health card, use the following information:11
Do you need to call 911 if using NARCAN® Nasal Spray?
- Yes, NARCAN® Nasal Spray can be administered before emergency medical assistance becomes available, but it is not intended to be a substitute for professional medical care. Emergency medical assistance (calling 911) should be requested immediately when an opioid overdose is suspected, before administering NARCAN® Nasal Spray.10
How much time between doses does there need to be?
- Multiple doses of NARCAN® Nasal Spray may be required until emergency medical assistance becomes available.10
If the patient responds to the first dose of NARCAN® Nasal Spray but relapses back into respiratory depression before emergency assistance arrives, administer repeated doses of NARCAN® Nasal Spray as necessary. If the patient does not respond to the first dose of NARCAN® Nasal Spray after 2-3 minutes, administer repeated doses using alternate nostril as necessary.10 How do you order NARCAN® Nasal Spray kits?
- Orders for NARCAN® Nasal Spray can be made by calling Emergent BioSolutions Canada Inc. at 1-844-898-0657 or by emailing customerservicecanada@ebsi.com.
How many NARCAN® Nasal Spray kits can you hand out to a person?
- In Ontario, up to two NARCAN® Nasal Spray kits can be given to a patient at a time.11 In Quebec, up to four NARCAN® Nasal Spray kits can be given to a patient at a time.18
Is one dose of NARCAN® Nasal Spray sufficient to reverse an opioid overdose?
- Not always, some patients may need multiple doses. The requirement for repeat doses of NARCAN® Nasal Spray depends upon the amount, type, and route of administration of the opioid being antagonized.10
If the patient does not respond within 2-3 minutes to the first dose of NARCAN® Nasal Spray, administer an additional dose of naloxone every 2-3 minutes (if additional doses are available), using a new NARCAN® Nasal Spray device for each dose using alternate nostril, until the desired response is obtained.10
References: 1. Tsuyuki R et al. Canadian national consensus guidelines for naloxone prescribing by pharmacists. Canadian Pharmacists Journal. 2020;153(6):347-351. 2. Government of Canada. Canada’s Opioid Crisis. Available at: https://www.canada.ca/content/dam/hc-sc/documents/services/publications/healthy-living/canada-opioid-crisis.pdf(Open in a new window). Accessed July 27, 2021. 3. Ontario Pharmacists Association. Pharmacist clinical tool for initiating naloxone discussions. Available at: https://opatoday.com/wp-content/uploads/Practice/Tools/Naloxone/Pharmacist-Clinical-Tool-for-Initiating-Naloxone-Discussions.pdf(Open in a new window). Accessed July 27, 2021. 4. Government of Quebec. Risks of opioid overdose. Available at: https://www.quebec.ca/en/health/advice-and-prevention/alcohol-drugs-gambling/risks-of-opioid-use(Open in a new window). Accessed July 27, 2021. 5. Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain—United States, 2016. MMWR Recomm Rep. 2016;65(1):1-50. 6. U.S. Department of Health & Human Services. U.S. surgeon general’s advisory on naloxone and opioid overdose. Available at: https://www.hhs.gov/surgeongeneral/priorities/opioids-and-addiction/naloxone-advisory/index.html(Open in a new window). Accessed July 27, 2021. 7. Dassieu L, Heino A, Develay É, et al. “They think you’re trying to get the drug”: Qualitative investigation of chronic pain patients’ health care experiences during the opioid overdose epidemic in Canada. Canadian Journal of Pain. 2021;5(1):66-80. 8. Government of Canada. Opioid overdose. Available at: https://www.canada.ca/en/health-canada/services/substance-use/problematic-prescription-drug-use/opioids/overdose.html(Open in a new window). Accessed July 27, 2021. 9. Gomes, T et al. Comparing the contribution of prescribed opioids to opioid-related hospitalizations across Canada: A multi-jurisdictional cross-sectional study. Drug and Alcohol Dependence. 2018;191:86-90. 10. NARCAN® Nasal Spray Product Monograph. Emergent BioSolutions Canada Ltd. March 5, 2021. 11. Ministry of Health and Long-Term Care: Ontario Public Drug Programs. Funding of Naloxone Nasal Spray through the ONPP and Updates to the Existing Program. 2018. Available at: http://www.health.gov.on.ca/en/pro/programs/drugs/opdp_eo/notices/exec_office_20180321.pdf(Open in a new window). Accessed July 27, 2021. 12. Quebec: Régie de l’assurance maladie. Programme de gratuité du médicament naloxone et de certaines fournitures. 2017. Available at: https://www.ramq.gouv.qc.ca/SiteCollectionDocuments/professionnels/infolettres/2017/info235-7.pdf(Open in a new window). Accessed July 27, 2021. 13. Government of Canada. Naloxone Nasal Spray now available to First Nations and Inuit through Non-Insured Health Benefits program. Available at: https://www.canada.ca/en/indigenous-services-canada/news/2018/04/naloxone-nasal-spray-now-available-to-first-nations-and-inuit-through-non-insured-health-benefits-program.html(Open in a new window). Accessed July 27, 2021. 14. Veteran Affairs Canada. NARCAN NASAL SPRAY 4MG/0.1ML. Available at: https://www.veterans.gc.ca/eng/financial-support/medical-costs/treatment-benefits/poc10/search/form_detail/02458187(Open in a new window). Accessed July 27, 2021. 15. First Nations Health Authority. Nasal Naloxone Listed as a Health Benefit for First Nations in BC. Available at: https://www.fnha.ca/Documents/FNHA-Nasal-Naloxone-Fact-Sheet.pdf(Open in a new window). Accessed July 27, 2021. 16. Government of Canada. Naloxone. Available at: https://www.canada.ca/en/health-canada/services/substance-use/problematic-prescription-drug-use/opioids/naloxone.html(Open in a new window). Accessed July 27, 2021. 17. Quebec: Régie de l’assurance maladie. Instructions de facturation pour le remboursement du médicament naloxone et de certaines fournitures. 2017. Available at: https://www.ramq.gouv.qc.ca/SiteCollectionDocuments/professionnels/infolettres/2017/info256-7.pdf(Open in a new window). Accessed July 27, 2021. 18. Quebec: Régie de l’assurance maladie. Ajout du vaporisateur nasal NarcanMC et de certaines fournitures au Programme de gratuité du médicament naloxone et de certaines fournitures. 2018. Available at: https://www.ramq.gouv.qc.ca/SiteCollectionDocuments/professionnels/infolettres/2018/info046-8.pdf(Open in a new window). Accessed February 24, 2022. 19. Canadian Pharmacy Association. Pharmacy in Canada. Available at: http://www.pharmacists.ca/cpha-ca/assets/File/pharmacy-in-canada/Pharmacy%20in%20Canada.pdf(Open in a new window). Accessed July 27, 2021. 20. Antoniou T, Pritlove C, Shearer D, et al. A qualitative study of a publicly funded pharmacy-dispensed naloxone program. International Journal of Drug Policy. 2021;92:103146. 21. Steinhauser K. Everyone is a little bit biased. American Bar Association. Available at: https://www.americanbar.org/groups/business_law/publications/blt/2020/04/everyone-is-biased/(Open in a new window). Accessed August 3, 2021 22. FitzGerald C, Hurst S. Implicit bias in healthcare professionals: A systematic review. BMC Medical Ethics. 2017;18(1):19. 23. College of Pharmacists of British Columbia. A Message from Our Board Chair: Understanding How Stigma Can Impact Patient Care. March 23, 2018. Available at: https://www.bcpharmacists.org/readlinks/message-our-board-chair-understanding-how-stigma-can-impact-patient-care(Open in a new window). Accessed July 27, 2021. 24. Public Health Ontario. Opioid Mortality Surveillance Report: Analysis of Opioid-Related Deaths in Ontario July 2017–June 2018. June 2019. Available at: https://www.publichealthontario.ca/-/media/documents/O/2019/opioid-mortality-surveillance-report.pdf(Open in a new window). Accessed July 27, 2021. 25. Healthline. Tylenol with Codeine Overdose. Available at: https://www.healthline.com/health/acetaminophen-and-codeine-overdose(Open in a new window). Accessed July 27, 2021. 26. Mayo Clinic. What are opioids and why are they dangerous? Available at: https://www.mayoclinic.org/diseases-conditions/prescription-drug-abuse/expert-answers/what-are-opioids/faq-20381270(Open in a new window). Accessed July 27, 2021.
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